Response to reactive oxygen species

Across TCGA patient cohorts, RNA activity of the Response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YWHAEP7, STARD13, and CD27, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to reactive oxygen species activity versus YWHAEP7 in OV (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	YWHAEP7 →	-1.321	-0.222	.005	.001	3	2
COAD	STARD13 →	-0.397	-0.101	.004	.001	3	2
COAD	CD27 →	+0.794	+0.134	<.001	.001	3	2
COAD	TMEM200A →	+1.003	+0.110	<.001	.004	3	2
COAD	GLYATL1 →	-0.783	-0.138	.002	.004	3	2
BRCA	C12orf77 →	+0.050	+0.236	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000302 vs YWHAEP7 — OV

Explore this scatter interactively →