Nuclear-transcribed mRNA poly(A) tail shortening

Across TCGA patient cohorts, RNA activity of the Nuclear-transcribed mRNA poly(A) tail shortening pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC186, FERMT2, and VCAN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear-transcribed mRNA poly(A) tail shortening activity versus CCDC186 in HNSC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCDC186 →	-0.247	-0.065	<.001	.007	3	6
OV	FERMT2 →	+0.448	+0.072	<.001	.001	3	6
CCRCC	VCAN →	+0.844	+0.039	<.001	<.001	3	6
GBM	RPL26 →	-0.570	-0.069	.004	.002	3	5
HNSC	SH2D3A_S180 →	-0.755	-0.074	<.001	<.001	3	5
LUAD	STAG2 →	+0.230	+0.051	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000289 vs CCDC186 — HNSC

Explore this scatter interactively →