Nuclear-transcribed mRNA poly(A) tail shortening

Across TCGA patient cohorts, RNA activity of the Nuclear-transcribed mRNA poly(A) tail shortening pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C6orf141, BNIP1, and ACOT9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear-transcribed mRNA poly(A) tail shortening activity versus C6orf141 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C6orf141 →	+0.661	+0.667	.002	.003	3	4
UCEC	BNIP1 →	+0.575	+0.154	.003	.003	2	5
PDAC	ACOT9 →	+0.325	+0.676	.001	.006	2	5
UCEC	TANK →	+0.510	+0.165	.005	.002	3	4
GBM	IQGAP1 →	+0.649	+0.427	<.001	.007	3	4
GBM	ANXA2 →	+0.958	+0.553	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000289 vs C6orf141 — OV

Explore this scatter interactively →