Mitotic cytokinesis

Across TCGA cell cohorts, RNA activity of the Mitotic cytokinesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF23, AURKB, and BIRC5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF23 grouped by Mitotic cytokinesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KIF23 →	-0.494	-0.288	.004	.001	2	10
URINARY_TRACT	AURKB →	-0.500	-0.332	<.001	.006	3	7
PANCREAS	BIRC5 →	-0.407	-0.150	.006	.009	3	6
LUNG_NSCLC_LUAD	KMT2D →	-0.209	-0.198	.004	.003	3	6
BREAST	PRDM12 →	+0.178	+0.141	<.001	.004	3	5
OESOPHAGUS	TMC4 →	-0.263	-0.338	.006	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF23 by Mitotic cytokinesis activity — BLOOD_Leukemia

Explore this box plot interactively →