Mitotic cytokinesis

Across TCGA cell cohorts, RNA activity of the Mitotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRX3, RPL26L1, and SRSF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRX3 grouped by Mitotic cytokinesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IRX3 →	-1.378	-0.148	<.001	.001	3	5
LUNG_SCLC	RPL26L1 →	-0.933	-0.164	.008	.006	2	6
PANCREAS	SRSF2 →	-0.415	-0.186	.005	.006	3	4
PANCREAS	ZDHHC3 →	+0.637	+0.215	.006	.005	2	5
PANCREAS	THAP11 →	-0.484	-0.236	.009	.004	2	5
OVARY	R3HDM4 →	+0.898	+0.303	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRX3 by Mitotic cytokinesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →