Mitotic cytokinesis

Across TCGA cell cohorts, RNA activity of the Mitotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C19orf38, ZNF709, and TINF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic cytokinesis activity versus C19orf38 in BLOOD_Leukemia (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C19orf38 →	-1.706	-0.127	.002	.002	3	4
BLOOD_Leukemia	ZNF709 →	+0.524	+0.208	.001	.001	3	4
BLOOD_Leukemia	TINF2 →	+0.649	+0.205	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZDHHC11 →	-1.554	-0.156	.003	.008	3	4
BLOOD_Myeloma	IDH2 →	+4.616	+0.203	<.001	.003	3	4
LUNG_NSCLC_LUAD	MXD3 →	+0.574	+0.112	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000281 vs C19orf38 — BLOOD_Leukemia

Explore this scatter interactively →