Polysaccharide catabolic process

Across TCGA patient cohorts, RNA activity of the Polysaccharide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EXOC6B, KRT19, and SEC24A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polysaccharide catabolic process activity versus EXOC6B in LSCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EXOC6B →	+0.224	+0.046	.001	.003	3	5
LSCC	KRT19 →	+0.721	+0.053	.001	<.001	3	5
CCRCC	SEC24A →	-0.290	-0.052	<.001	.001	3	5
PDAC	TNPO2 →	+0.197	+0.056	.007	<.001	3	5
PDAC	CD109 →	+0.473	+0.057	.001	.001	3	5
UCEC	PFKM →	+0.510	+0.072	<.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000272 vs EXOC6B — LSCC

Explore this scatter interactively →