Polysaccharide catabolic process

Across TCGA patient cohorts, RNA activity of the Polysaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TET1, MSL2, and CEACAM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polysaccharide catabolic process activity versus TET1 in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TET1 →	-0.534	-0.162	.002	.004	3	6
GBM	MSL2 →	-0.345	-0.262	<.001	<.001	3	5
LSCC	CEACAM3 →	+0.705	+0.224	<.001	<.001	3	5
LSCC	ADGRG3 →	+0.949	+0.187	<.001	<.001	3	5
GBM	PRPF38A →	-0.339	-0.157	<.001	<.001	3	5
GBM	ZNF197 →	-0.354	-0.254	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000272 vs TET1 — GBM

Explore this scatter interactively →