Polysaccharide catabolic process

Across TCGA cell cohorts, RNA activity of the Polysaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOL4L, NCEH1, and ATP6V1D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOL4L grouped by Polysaccharide catabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NOL4L →	+1.111	+1.014	.008	.003	3	4
BLOOD_Myeloma	NCEH1 →	-0.755	-1.522	.003	<.001	2	4
LUNG_NSCLC_LUSC	ATP6V1D →	-0.836	-1.012	<.001	.003	3	3
LUNG_NSCLC_LUSC	HOXA5 →	+2.154	+1.421	<.001	.001	3	3
LUNG_NSCLC_LUSC	DNPH1 →	+1.057	+0.944	.009	.007	3	3
LUNG_NSCLC_LUSC	TRIM24 →	+1.018	+1.127	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOL4L by Polysaccharide catabolic process activity — SOFT_TISSUE

Explore this box plot interactively →