Polysaccharide catabolic process

Across TCGA cell cohorts, RNA activity of the Polysaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAA, CPNE7, and RRAGD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polysaccharide catabolic process activity versus GAA in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GAA →	+1.267	+0.672	<.001	.008	3	6
UPPER_AERODIGESTIVE_TRACT	CPNE7 →	+1.526	+1.340	.006	.001	3	5
BLOOD_Lymphoma	RRAGD →	+2.677	+1.283	.001	.001	3	5
BLOOD_Leukemia	BCL2 →	+1.566	+0.831	<.001	.002	2	5
LARGE_INTESTINE	EDN1 →	-1.666	-0.809	<.001	.005	3	4
OVARY	P4HB →	+1.039	+1.301	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000272 vs GAA — BLOOD_Leukemia

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