Peptidoglycan metabolic process

Across TCGA patient cohorts, RNA activity of the Peptidoglycan metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSD4, HCLS1, and WIPF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidoglycan metabolic process activity versus PSD4 in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSD4 →	-0.449	-0.068	<.001	<.001	3	5
LSCC	HCLS1 →	-0.350	-0.378	.003	<.001	3	5
GBM	WIPF1 →	-0.277	-0.059	.002	.006	3	5
GBM	ARPC1B →	-0.464	-0.067	<.001	<.001	3	5
GBM	VIM_S412 →	-0.809	-0.071	<.001	<.001	3	4
GBM	INPP5D →	-0.425	-0.064	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000270 vs PSD4 — GBM

Explore this scatter interactively →