Peptidoglycan metabolic process

Across TCGA patient cohorts, RNA activity of the Peptidoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTBK2, LATS2, and P4HA2-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidoglycan metabolic process activity versus TTBK2 in CCRCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TTBK2 →	+0.261	+0.766	.006	.004	3	3
CCRCC	LATS2 →	+0.543	+0.885	.001	<.001	3	3
CCRCC	P4HA2-AS1 →	+0.735	+0.989	.002	<.001	3	3
BRCA	TNS3 →	+0.942	+1.068	.003	<.001	3	3
BRCA	ADSS1 →	+0.933	+1.144	.007	<.001	3	3
BRCA	RRN3P1 →	+1.073	+1.000	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000270 vs TTBK2 — CCRCC

Explore this scatter interactively →