Peptidoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Peptidoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAX2, SELENBP1, and COG5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VAX2 grouped by Peptidoglycan metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VAX2 →	+1.261	+0.303	.002	.001	3	4
LIVER	SELENBP1 →	+4.466	+1.931	.002	<.001	3	3
LUNG_NSCLC_LUSC	COG5 →	-1.714	-2.315	.001	<.001	3	3
LIVER	TRAPPC2L →	+0.293	+1.931	.007	<.001	3	3
LIVER	XYLB →	+1.376	+1.931	.004	<.001	3	3
BREAST	TTC17 →	+0.547	+0.798	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VAX2 by Peptidoglycan metabolic process activity — OESOPHAGUS

Explore this box plot interactively →