Mitochondrial fission

Across TCGA patient cohorts, RNA activity of the Mitochondrial fission pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZEB2, SFRP4, and ELK3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fission activity versus ZEB2 in OV (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZEB2 →	-0.720	-0.169	.007	.002	3	7
OV	SFRP4 →	-2.421	-0.193	<.001	.001	3	6
OV	ELK3 →	-0.778	-0.214	.002	<.001	3	6
OV	SPARC →	-1.481	-0.221	<.001	<.001	3	6
OV	FAP →	-1.987	-0.164	<.001	.002	3	6
HNSC	MGP →	-0.868	-0.102	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000266 vs ZEB2 — OV

Explore this scatter interactively →