Allantoin metabolic process

Across TCGA patient cohorts, RNA activity of the Allantoin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA, EFHD2, and TOP2B_S1552, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Allantoin metabolic process activity versus ADA in GBM (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADA →	+0.605	+0.103	<.001	<.001	3	6
OV	EFHD2 →	+0.342	+0.060	.006	.004	3	6
BRCA	TOP2B_S1552 →	-0.446	-0.072	.002	<.001	3	5
UCEC	GDA →	+0.990	+0.108	<.001	<.001	3	5
LSCC	PLAU →	+0.492	+0.063	.001	.007	3	5
BRCA	SCCPDH →	-0.536	-0.077	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000255 vs ADA — GBM

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