Allantoin metabolic process

Across TCGA patient cohorts, RNA activity of the Allantoin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDA, ZBED2, and NAXE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Allantoin metabolic process activity versus GDA in HNSC (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GDA →	+1.958	+0.202	<.001	<.001	3	4
HNSC	ZBED2 →	+1.081	+0.175	<.001	<.001	3	4
LUAD	NAXE →	-0.435	-0.161	.001	.001	3	4
LUAD	HOXC9 →	-0.913	-0.206	.001	<.001	3	4
UCEC	DAPP1 →	+0.782	+0.169	<.001	<.001	3	4
HNSC	VASH2 →	-0.665	-0.158	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000255 vs GDA — HNSC

Explore this scatter interactively →