Allantoin metabolic process

Across TCGA cell cohorts, RNA activity of the Allantoin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D19, RPP30, and OXA1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Allantoin metabolic process activity versus TBC1D19 in BLOOD_Leukemia (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TBC1D19 →	-0.621	-0.226	.003	<.001	3	4
BLOOD_Leukemia	RPP30 →	-0.855	-0.256	<.001	<.001	3	4
BLOOD_Leukemia	OXA1L →	+0.521	+0.195	.002	.002	3	4
OVARY	FOXE1 →	-1.440	-1.525	.005	.006	3	4
SOFT_TISSUE	LSM14A →	-0.697	-2.041	.006	<.001	3	3
SOFT_TISSUE	MSH2 →	-1.109	-2.041	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000255 vs TBC1D19 — BLOOD_Leukemia

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