Protein polyubiquitination

Across TCGA cell cohorts, RNA activity of the Protein polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB7B, NPM1, and OAZ3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB7B grouped by Protein polyubiquitination-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZBTB7B →	+1.142	+0.168	.004	.006	2	5
OESOPHAGUS	NPM1 →	-0.779	-0.178	.001	.004	3	4
LARGE_INTESTINE	OAZ3 →	+0.620	+0.149	.001	.008	3	4
KIDNEY	BST1 →	+1.993	+0.206	.009	.001	3	4
OVARY	ITGB1 →	-1.266	-0.168	.001	.002	3	4
PANCREAS	PRSS36 →	+0.634	+0.145	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB7B by Protein polyubiquitination activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →