"Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA patient cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-202P, FFAR2, and CPA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity versus RNU6-202P in COAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-202P →	+0.259	+0.244	.001	<.001	3	4
HNSC	FFAR2 →	-0.842	-0.114	<.001	.006	3	4
UCEC	CPA3 →	-1.182	-0.153	.006	.006	2	5
GBM	EMC3-AS1 →	+0.551	+0.159	.001	.001	3	4
HNSC	OR7E122P →	+0.150	+0.169	.002	.005	3	4
GBM	FANCD2OS →	+0.315	+0.117	.006	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000184 vs RNU6-202P — COAD

Explore this scatter interactively →