"Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA cell cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF644, DMAC1, and CFAP44, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF644 grouped by "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF644 →	-1.381	-0.154	.001	.001	3	5
LUNG_NSCLC_LUAD	DMAC1 →	-0.739	-0.102	.003	.008	3	4
BLOOD_Myeloma	CFAP44 →	-0.877	-0.141	.007	.006	3	4
PANCREAS	HIF1A →	+1.009	+0.115	.002	.007	3	4
PANCREAS	EIF3E →	-0.759	-0.151	.005	.007	3	4
OVARY	MESD →	+0.679	+0.123	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF644 by "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity — BLOOD_Myeloma

Explore this box plot interactively →