"Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA cell cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YAE1, SPRN, and TEX22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity versus YAE1 in OESOPHAGUS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	YAE1 →	+0.942	+0.239	.003	.007	2	5
URINARY_TRACT	SPRN →	+0.718	+0.264	.003	.005	3	4
URINARY_TRACT	TEX22 →	+0.572	+0.372	.006	.002	3	4
PANCREAS	ESCO2 →	+1.206	+0.361	<.001	.005	3	4
SOFT_TISSUE	EDEM3 →	-0.683	-0.137	.007	.004	3	4
PANCREAS	PRPF4 →	+0.680	+0.310	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000184 vs YAE1 — OESOPHAGUS

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