rRNA modification

Across TCGA patient cohorts, RNA activity of the rRNA modification pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THOC7, KIF2A, and MAP9_S79, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA modification activity versus THOC7 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THOC7 →	+0.231	+0.025	<.001	<.001	3	5
CCRCC	KIF2A →	+0.385	+0.026	.002	.003	3	4
CCRCC	MAP9_S79 →	+0.455	+0.023	.002	<.001	3	4
BRCA	SEPSECS →	+0.239	+0.020	.002	<.001	3	4
BRCA	SPR →	+0.313	+0.017	.004	<.001	3	4
LSCC	BAIAP2L2_S429 →	-1.410	-0.034	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000154 vs THOC7 — OV

Explore this scatter interactively →