rRNA modification

Across TCGA patient cohorts, RNA activity of the rRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LHFPL6, ZBTB47, and CNRIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA modification activity versus LHFPL6 in BRCA (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LHFPL6 →	-0.929	-0.215	<.001	<.001	3	8
OV	ZBTB47 →	-0.515	-0.167	.002	.006	3	7
BRCA	CNRIP1 →	-0.827	-0.243	<.001	<.001	3	7
OV	ENTPD1 →	-0.402	-0.261	.002	<.001	3	7
OV	DDR2 →	-1.014	-0.219	.002	.002	3	7
LSCC	ZCCHC24 →	-0.687	-0.380	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000154 vs LHFPL6 — BRCA

Explore this scatter interactively →