rRNA modification

Across TCGA cell cohorts, RNA activity of the rRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARSD, GYS1, and LXN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARSD grouped by rRNA modification-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARSD →	-1.481	-0.280	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	GYS1 →	+0.801	+0.352	.004	.005	3	4
SOFT_TISSUE	LXN →	-4.238	-0.598	.002	<.001	3	4
OVARY	PRCC →	-0.640	-0.212	.001	.001	3	4
SKIN	USP41 →	-1.539	-0.342	.003	.002	3	4
PANCREAS	IQCE →	-0.639	-0.283	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARSD by rRNA modification activity — LARGE_INTESTINE

Explore this box plot interactively →