rRNA modification

Across TCGA cell cohorts, RNA activity of the rRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNPEPL1, PDE6D, and SDHA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA modification activity versus RNPEPL1 in LUNG_NSCLC_LUSC (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RNPEPL1 →	-1.195	-0.219	.001	.002	3	5
LUNG_NSCLC_LUSC	PDE6D →	-0.934	-0.252	.007	<.001	3	5
LUNG_NSCLC_LUAD	SDHA →	-0.764	-0.247	.001	<.001	3	5
CNS	AMACR →	-0.821	-0.248	.003	.001	3	5
BLOOD_Leukemia	PTPRN2 →	-1.443	-0.182	.002	.003	3	5
OVARY	LTB →	+2.627	+0.285	.009	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000154 vs RNPEPL1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →