Sulfur amino acid transport

Across TCGA patient cohorts, RNA activity of the Sulfur amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02825, LRRC17, and DCBLD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid transport activity versus LINC02825 in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC02825 →	+0.289	+0.209	.005	.003	3	3
HNSC	LRRC17 →	-0.913	-0.174	.007	.003	3	3
GBM	DCBLD2 →	-0.714	-0.347	.001	<.001	3	3
PDAC	ANKRD36C →	-0.912	-0.734	<.001	<.001	3	3
UCEC	MYOM1 →	-0.571	-0.595	.006	<.001	3	3
GBM	SLC6A7 →	+0.929	+0.334	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000101 vs LINC02825 — LUAD

Explore this scatter interactively →