Sulfur amino acid transport

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AZ1, PEBP1, and HNRNPM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2AZ1 grouped by Sulfur amino acid transport-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	H2AZ1 →	-2.300	-1.921	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PEBP1 →	-1.091	-1.494	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	HNRNPM →	-1.348	-1.512	.001	<.001	3	5
LUNG_SCLC	CENPN →	-0.884	-1.166	.004	.007	3	4
BONE	CMC2 →	-0.977	-0.554	.005	<.001	3	4
OESOPHAGUS	HSPE1 →	-0.765	-1.027	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2AZ1 by Sulfur amino acid transport activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →