Sulfur amino acid transport

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, SLC3A2, and CAPN5, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid transport activity versus SLC7A5 in PANCREAS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC7A5 →	+2.176	+0.401	.004	<.001	3	11
LUNG_NSCLC_LUAD	SLC3A2 →	+1.402	+0.405	<.001	<.001	3	7
LARGE_INTESTINE	CAPN5 →	-2.861	-0.442	<.001	<.001	3	5
URINARY_TRACT	RABEP2 →	-0.798	-0.235	.006	.006	3	5
LIVER	SLC2A1 →	+2.693	+0.336	<.001	<.001	3	5
CNS	PDGFB →	+1.529	+0.263	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000101 vs SLC7A5 — PANCREAS

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