Sulfur amino acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Sulfur amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTH, TXN2P1, and SEH1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid biosynthetic process activity versus CTH in UCEC (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTH →	+0.710	+0.199	<.001	.001	3	4
LSCC	TXN2P1 →	-0.414	-0.094	.001	.008	3	4
LSCC	SEH1L →	-0.437	-0.155	<.001	<.001	3	4
COAD	DAGLA →	-0.521	-0.118	.003	.005	3	3
GBM	RN7SL674P →	+0.524	+0.119	<.001	.009	3	3
UCEC	SGO1 →	-0.671	-0.140	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000097 vs CTH — UCEC

Explore this scatter interactively →