Sulfur amino acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DISC1, YLPM1, and DUS4L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DISC1 grouped by Sulfur amino acid biosynthetic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DISC1 →	-1.154	-1.476	.005	.004	3	4
LUNG_SCLC	YLPM1 →	-0.636	-1.189	.007	.007	3	4
LUNG_NSCLC_LUAD	DUS4L →	-0.536	-0.817	.002	.005	3	4
LUNG_NSCLC_LUAD	COPZ2 →	-1.358	-0.888	.009	.003	3	4
OESOPHAGUS	DPY19L1 →	+1.177	+0.933	<.001	.001	3	4
OESOPHAGUS	NAALADL1 →	+0.475	+1.150	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DISC1 by Sulfur amino acid biosynthetic process activity — BONE

Explore this box plot interactively →