Sulfur amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Sulfur amino acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LARP4B_S736, VCAN, and MAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid metabolic process activity versus LARP4B_S736 in OV (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LARP4B_S736 →	-1.075	-0.039	<.001	<.001	3	5
BRCA	VCAN →	+0.722	+0.028	<.001	<.001	3	5
LSCC	MAP2 →	+0.778	+0.036	<.001	.001	3	5
LSCC	NCF1 →	-0.453	-0.035	.006	.009	3	5
BRCA	HSPA12A →	+0.448	+0.028	<.001	<.001	3	5
CCRCC	MTAP →	+0.268	+0.058	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000096 vs LARP4B_S736 — OV

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