Sulfur amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Sulfur amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAE1, UBE2C, and RTKN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid metabolic process activity versus RAE1 in COAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAE1 →	-0.585	-0.154	.001	.004	3	5
GBM	UBE2C →	-1.205	-0.225	<.001	<.001	3	5
UCEC	RTKN2 →	-0.700	-0.191	<.001	<.001	3	5
GBM	CDCA5 →	-0.930	-0.251	<.001	<.001	3	5
GBM	NDC80 →	-1.043	-0.222	<.001	<.001	3	5
GBM	CCDC18 →	-0.423	-0.188	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000096 vs RAE1 — COAD

Explore this scatter interactively →