Sulfur amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F6, MAFG, and RAB35, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, E2F6 grouped by Sulfur amino acid metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	E2F6 →	-0.186	-0.249	<.001	.001	3	3
BLOOD_Leukemia	MAFG →	+0.171	+0.374	.001	<.001	3	3
LIVER	RAB35 →	+0.850	+0.286	.002	.005	3	3
PANCREAS	AKR1D1 →	-0.130	-0.226	.001	.001	3	3
LUNG_NSCLC_LUSC	KLF7 →	-0.211	-0.250	.005	<.001	3	3
LUNG_NSCLC_LUSC	S100A12 →	-0.156	-0.329	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

E2F6 by Sulfur amino acid metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →