Sulfur amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJB6, GPR160, and ZC3H4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid metabolic process activity versus DNAJB6 in KIDNEY (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DNAJB6 →	-0.728	-0.288	.004	<.001	3	4
LARGE_INTESTINE	GPR160 →	+1.662	+0.193	.008	.006	2	5
PANCREAS	ZC3H4 →	+0.670	+0.187	.002	<.001	3	4
PANCREAS	MLLT6 →	+0.992	+0.179	.005	.005	3	3
KIDNEY	SLC27A3 →	+2.037	+0.335	.004	<.001	2	4
KIDNEY	KANSL1L →	+1.694	+0.327	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000096 vs DNAJB6 — KIDNEY

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