DNA replication checkpoint signaling

Across TCGA cell cohorts, RNA activity of the DNA replication checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PALB2, ASCC3, and NEURL1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PALB2 grouped by DNA replication checkpoint signaling-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PALB2 →	-0.504	-0.178	<.001	.005	3	4
SKIN	ASCC3 →	+0.697	+0.234	<.001	.002	3	4
SKIN	NEURL1B →	-0.845	-0.206	.007	.005	3	4
SOFT_TISSUE	HSPA4L →	+1.758	+0.289	.008	.005	3	4
SOFT_TISSUE	ILRUN →	-0.554	-0.166	.002	.009	3	4
BREAST	GALNS →	+1.147	+0.218	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PALB2 by DNA replication checkpoint signaling activity — OVARY

Explore this box plot interactively →