DNA replication checkpoint signaling

Across TCGA cell cohorts, RNA activity of the DNA replication checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBXN7, SAAL1, and TMED3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA replication checkpoint signaling activity versus UBXN7 in BLOOD_Leukemia (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBXN7 →	+0.914	+1.128	<.001	<.001	3	6
BREAST	SAAL1 →	+0.729	+0.889	<.001	<.001	3	6
BLOOD_Leukemia	TMED3 →	-0.894	-0.969	<.001	<.001	3	6
LUNG_NSCLC_LUAD	ABCC3 →	-1.491	-0.626	.005	.002	3	6
BREAST	DBF4B →	+0.919	+1.143	<.001	<.001	3	6
BREAST	NR1D2 →	+1.229	+0.979	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000076 vs UBXN7 — BLOOD_Leukemia

Explore this scatter interactively →