Cell cycle checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H12A, RFK, and TIMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle checkpoint signaling activity versus ZC3H12A in LUNG_SCLC (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZC3H12A →	-1.286	-0.151	<.001	<.001	3	5
LARGE_INTESTINE	RFK →	-0.799	-0.162	.002	<.001	3	4
LARGE_INTESTINE	TIMP2 →	+2.799	+0.127	<.001	.003	3	4
BLOOD_Leukemia	RMDN3 →	-0.672	-0.129	<.001	.005	3	4
STOMACH	NDUFA10 →	-0.807	-0.232	<.001	<.001	3	4
BLOOD_Leukemia	YOD1 →	-1.147	-0.125	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000075 vs ZC3H12A — LUNG_SCLC

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