Mitotic sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Mitotic sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS15, C11orf54, and MND1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPS15 grouped by Mitotic sister chromatid segregation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MRPS15 →	-0.857	-0.219	<.001	<.001	3	6
LUNG_NSCLC_LUSC	C11orf54 →	-0.978	-0.131	<.001	.007	3	5
LIVER	MND1 →	-1.061	-0.176	.002	.001	3	4
URINARY_TRACT	RECQL4 →	-0.770	-0.203	.004	.005	3	4
URINARY_TRACT	BCS1L →	-0.761	-0.203	.009	.005	3	4
LARGE_INTESTINE	MED31 →	-0.649	-0.106	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPS15 by Mitotic sister chromatid segregation activity — SOFT_TISSUE

Explore this box plot interactively →