Mitotic sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Mitotic sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF367, ZNF71, and ZBTB12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic sister chromatid segregation activity versus ZNF367 in PANCREAS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF367 →	+1.387	+0.283	.001	<.001	3	6
BLOOD_Leukemia	ZNF71 →	+0.597	+0.201	.004	.004	3	5
BLOOD_Lymphoma	ZBTB12 →	+0.933	+0.165	.009	<.001	3	5
BLOOD_Leukemia	UHRF1 →	+1.676	+0.140	<.001	<.001	3	5
SOFT_TISSUE	DBF4B →	+1.043	+0.203	.001	.008	3	5
BREAST	ZCCHC18 →	+1.041	+0.203	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000070 vs ZNF367 — PANCREAS

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