Ribosomal small subunit export from nucleus

Across TCGA patient cohorts, RNA activity of the Ribosomal small subunit export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD8, WDR36, and NEMF, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit export from nucleus activity versus CHD8 in KICH (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	CHD8 →	+0.790	+0.061	<.001	<.001	3	33
UVM	WDR36 →	+1.595	+0.085	<.001	<.001	3	33
UVM	NEMF →	+1.559	+0.088	<.001	<.001	3	33
UVM	RIOK2 →	+1.267	+0.085	<.001	<.001	3	33
ACC	ZC3H14 →	+1.045	+0.055	<.001	<.001	3	32
UVM	NUP88 →	+1.053	+0.080	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000056 vs CHD8 — KICH

Explore this scatter interactively →