Ribosomal small subunit export from nucleus

Across TCGA patient cohorts, RNA activity of the Ribosomal small subunit export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTTN_T401, THTPA, and AFF4_S836, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit export from nucleus activity versus CTTN_T401 in HNSC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CTTN_T401 →	-0.620	-0.061	<.001	<.001	3	6
CCRCC	THTPA →	+0.261	+0.029	.006	.008	3	6
LUAD	AFF4_S836 →	+0.736	+0.051	<.001	<.001	3	5
LSCC	PGRMC1_T74 →	-0.803	-0.043	<.001	<.001	3	5
PDAC	VPS13C_S1912 →	-0.650	-0.055	.005	.001	3	5
UCEC	EEF2_S502 →	-0.579	-0.066	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000056 vs CTTN_T401 — HNSC

Explore this scatter interactively →