Ribosomal small subunit export from nucleus

Across TCGA patient cohorts, RNA activity of the Ribosomal small subunit export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDC20_T70, DDX21_S121, and NPM1_S254, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit export from nucleus activity versus CDC20_T70 in LUAD (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDC20_T70 →	+0.957	+0.200	<.001	<.001	3	7
BRCA	DDX21_S121 →	+0.643	+0.183	<.001	<.001	3	7
LUAD	NPM1_S254 →	+1.113	+0.244	<.001	<.001	3	7
BRCA	NPM1_S70 →	+0.901	+0.230	<.001	<.001	3	7
CCRCC	NPM1_T199 →	+1.499	+0.287	<.001	<.001	3	7
BRCA	TBL3 →	+0.258	+0.225	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000056 vs CDC20_T70 — LUAD

Explore this scatter interactively →