Ribosomal subunit export from nucleus

Across TCGA patient cohorts, RNA activity of the Ribosomal subunit export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHF3, RPRD2, and ZMYM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal subunit export from nucleus activity versus PHF3 in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF3 →	+0.298	+0.088	<.001	<.001	3	6
UCEC	RPRD2 →	+0.393	+0.100	<.001	<.001	3	5
UCEC	ZMYM3 →	+0.359	+0.092	<.001	<.001	3	5
BRCA	BRD9 →	+0.123	+0.019	.001	.004	3	5
LUAD	SCAF8 →	+0.195	+0.043	<.001	<.001	3	5
GBM	PHF2_S905 →	+0.634	+0.042	.004	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000054 vs PHF3 — UCEC

Explore this scatter interactively →