Ribosomal subunit export from nucleus

Across TCGA patient cohorts, RNA activity of the Ribosomal subunit export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18A, CCNB1, and PTTG1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal subunit export from nucleus activity versus KIF18A in GBM (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIF18A →	+0.983	+0.235	<.001	.001	3	9
UCEC	CCNB1 →	+1.046	+0.199	<.001	<.001	3	9
BRCA	PTTG1 →	+1.000	+0.266	<.001	<.001	3	9
GBM	GINS1 →	+1.052	+0.258	<.001	<.001	3	9
GBM	NCAPG →	+1.074	+0.252	<.001	<.001	3	8
GBM	TTK →	+1.020	+0.234	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000054 vs KIF18A — GBM

Explore this scatter interactively →