Ribosomal subunit export from nucleus

Across TCGA cell cohorts, RNA activity of the Ribosomal subunit export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF6, CENPC, and SYS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal subunit export from nucleus activity versus EIF6 in OVARY (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EIF6 →	+0.883	+0.111	.002	.003	3	9
OVARY	CENPC →	-1.034	-0.125	<.001	.001	3	5
URINARY_TRACT	SYS1 →	+0.977	+0.091	.002	<.001	3	4
BREAST	THAP10 →	+0.835	+0.098	.007	.003	3	4
SOFT_TISSUE	RAB5IF →	+0.820	+0.121	.003	.004	3	4
OVARY	DDX5 →	-0.808	-0.090	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000054 vs EIF6 — OVARY

Explore this scatter interactively →