Citrulline metabolic process

Across TCGA cell cohorts, RNA activity of the Citrulline metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARMC2, CCDC115, and SLC19A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARMC2 grouped by Citrulline metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARMC2 →	-0.457	-0.546	<.001	.006	3	4
BREAST	CCDC115 →	+0.820	+0.583	<.001	.008	3	3
BLOOD_Myeloma	SLC19A2 →	+0.960	+0.416	<.001	.001	3	3
BLOOD_Myeloma	IFI6 →	-2.594	-0.438	.007	.005	3	3
OVARY	SMIM26 →	+0.590	+0.786	<.001	.001	3	3
LIVER	APBA2 →	+2.052	+1.511	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARMC2 by Citrulline metabolic process activity — CNS

Explore this box plot interactively →