Citrulline metabolic process

Across TCGA cell cohorts, RNA activity of the Citrulline metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASS1, RPS2, and COQ10B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrulline metabolic process activity versus ASS1 in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ASS1 →	+1.698	+0.210	.002	.001	3	5
STOMACH	RPS2 →	+1.075	+0.570	.005	<.001	3	5
URINARY_TRACT	COQ10B →	+0.615	+0.261	.001	.002	3	4
BONE	PEA15 →	-1.844	-0.280	.007	.005	3	4
LUNG_NSCLC_LUSC	DDX56 →	+0.587	+0.464	.005	.009	3	4
BONE	RUNX1 →	-2.846	-0.280	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000052 vs ASS1 — BREAST

Explore this scatter interactively →