Very long-chain fatty acid metabolic process

Across TCGA patient cohorts, RNA activity of the Very long-chain fatty acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOM1L1, SLC27A2, and NIN_S1550, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very long-chain fatty acid metabolic process activity versus TOM1L1 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TOM1L1 →	+0.637	+0.051	<.001	<.001	3	7
BRCA	SLC27A2 →	+0.694	+0.030	<.001	<.001	3	7
HNSC	NIN_S1550 →	-0.296	-0.055	.001	<.001	3	6
HNSC	RASSF2 →	-0.338	-0.050	.005	.002	3	6
UCEC	DDAH1 →	+0.573	+0.066	<.001	<.001	3	6
LSCC	LACTB2 →	+0.401	+0.040	.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000038 vs TOM1L1 — BRCA

Explore this scatter interactively →