Very long-chain fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Very long-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLK2, FRA10AC1, and MORN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLK2 grouped by Very long-chain fatty acid metabolic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TLK2 →	+0.733	+1.975	<.001	<.001	3	4
LUNG_NSCLC_LUAD	FRA10AC1 →	+0.582	+1.157	<.001	<.001	3	4
BLOOD_Myeloma	MORN4 →	+2.972	+1.427	<.001	.001	3	4
LUNG_NSCLC_LUSC	SEC14L2 →	+1.487	+1.394	<.001	<.001	3	4
LUNG_NSCLC_LUSC	GLTPD2 →	+0.386	+1.836	<.001	<.001	3	4
BONE	CUL2 →	-0.772	-1.378	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLK2 by Very long-chain fatty acid metabolic process activity — BLOOD_Lymphoma

Explore this box plot interactively →