Very long-chain fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Very long-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPL, ERP27, and SPINT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very long-chain fatty acid metabolic process activity versus PPL in LUNG_NSCLC_LUAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPL →	+1.409	+0.581	.001	.001	3	5
LUNG_NSCLC_LUAD	ERP27 →	+1.690	+0.601	.002	<.001	3	5
OVARY	SPINT1 →	+3.766	+1.022	<.001	.005	3	5
LUNG_NSCLC_LUAD	PRSS22 →	+2.268	+0.655	.002	.003	3	5
LUNG_NSCLC_LUAD	GRHL2 →	+2.553	+0.651	<.001	.007	3	5
STOMACH	LMBRD1 →	+1.239	+1.325	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000038 vs PPL — LUNG_NSCLC_LUAD

Explore this scatter interactively →